Physician CFS Study Abstract

NADH A NEW THERAPEUTIC APPROACH IN CHRONIC FATIGUE SYNDROME (CFS)

L.M. Forsyth, M.D.; A.L. MacDowell-Carnciro, M.D.; G.D. Birkmayer, M.D.; Ph.D.; H.G. Preuss, M.D.; and J.A. Bellanti, M.D.; Departments of Pediatrics and Microbiology-Immunology and the Immunology Center, Georgetown University Medical Center, Washington, D.C.

Background: Chronic fatigue syndrome (CFS) is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, and a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, muscle weakness, arthralgia, low-grade fever, sore throat, headache, sleep disturbances, and swelling and tenderness of lymph nodes. No effective treatment for CFS is known.

Objective: The purpose of the study was to evaluate the efficacy of the reduced form of nicotinamide adenine dinucleotide (NADH) administered orally in a randomized, double-blind, placebo-control, crossover study in patients with CFS. NADH is known to trigger energy production through ATP generation, which may form the basis of its potential effects. The study drug is ENADAŽ NADH the only stabilized absorbable oral form of NADH a nutritional supplement product.

Methods: Twenty-six evaluatable patients who fulfilled the CDC criteria for CFS completed the study. Medical history, physical examination, laboratory studies and questionnaire were obtained at baseline, 4, 8 and 12 weeks. Subjects were randomly assigned to receive either 10 mg of NADH (ENADAŽ) or placebo at week 0 for a four-week period, followed by a four-week wash-out period, followed by a final four-week period in which subjects were crossed to an alternative regimen.

Results: No adverse effects were observed related to the study drug. Within this cohort of twenty-six patients, four times more patients responded to NADH (ENADAŽ) compared to placebo.

Conclusion: Collectively, the results of this preliminary study indicate that NADH (ENADAŽ) may be an effective therapy in the management of the Chronic Fatigue Syndrome and suggest that further clinical trials be performed to establish its efficacy in this clinically perplexing disorder.

The study was published in the February 1999 issue of Annals of Allergy, Asthma and Immunology.

For further information, click here: CFS STUDY , then use your browser's BACK button to return to Wizards Gate's ENADA pages.

Wizards Gate is dedicated to bringing this valuable supplement to you at the lowest possible prices, and FREE Priority Mail Shipping when ordering two or more of any size ENADAŽ

To order ENADAŽ NADH The Energizing Coenzyme, click below

  WB00678_.gif (615 bytes)  ORDER NOW  WB00677_.gif (630 bytes)